The regional uptake of chloroquine in the rat brain
Identifieur interne : 003849 ( Main/Exploration ); précédent : 003848; suivant : 003850The regional uptake of chloroquine in the rat brain
Auteurs : Nosakhare G. Osifo [États-Unis]Source :
- Toxicology and Applied Pharmacology [ 0041-008X ] ; 1979.
English descriptors
- Teeft :
- Aberrant melanin pigmentation, Acute malarial fever, Bacterial pyrogen, Cardiovascular collapse, Catecholamine, Chloroquine, Chloroquine administration, Chloroquine diphosphate, Consistent pattern, Control rats, Corpus striatum, Dyskinesia, High uptake, Highest concentration, Involuntary movements, Malarial infection, Malarial patients, Medulla oblongata, Melanin, Melanin affinity, Nail beds, Osifo, Pituitary gland, Pyrogen, Pyrogen administration, Pyrogen pretreatment, Regional uptake, Respiratory distress, Reuptake mechanisms, Specific affinity, Striatum, Various regions.
Abstract
Abstract: The uptake of ip administered chloroquine diphosphate, 14 mg/ml/kg, into dissected regions of the rat brain with and without pyrogen pretreatment was investigated. A consistent pattern of uptake, not significantly altered by pyrogen pretreatment, was found. The highest concentration of chloroquine 1 hr after administration was found in the hypothalamus (1.278±0.114 μg/g; Mean ± SE), whereas the cortex (0.147±0.006 μg/g) had the lowest concentration. The corpus striatum (0.62±0.029 μg/g) had a smaller uptake than the hippocampus (0.693±0.011 μg/g), the cerebellum (0.676±0.055 μg/g), and the midbrain (0.644±0.053 μg/g). The difference of the uptake pattern from known catecholamine distribution in the rat brain leads to the conclusion that whereas no specific affinity of chloroquine for the catecholamine-rich regions have been proven, other unknown factors ensure a consistent pattern of chloroquine uptake. The implications of these findings in relation to the transient extrapyramidal disorders associated with the 4-aminoquinolines in some malarial patients, and the aberrant melanin pigmentation associated with the chronic use of chloroquine for some autoimmune diseases, are discussed.
Url:
DOI: 10.1016/0041-008X(79)90498-8
Affiliations:
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Osifo</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Department of Pharmacology & Toxicology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Toxicology and Applied Pharmacology</title><title level="j" type="abbrev">YTAAP</title><idno type="ISSN">0041-008X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1979">1979</date><biblScope unit="volume">50</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="109">109</biblScope><biblScope unit="page" to="114">114</biblScope></imprint><idno type="ISSN">0041-008X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0041-008X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Aberrant melanin pigmentation</term><term>Acute malarial fever</term><term>Bacterial pyrogen</term><term>Cardiovascular collapse</term><term>Catecholamine</term><term>Chloroquine</term><term>Chloroquine administration</term><term>Chloroquine diphosphate</term><term>Consistent pattern</term><term>Control rats</term><term>Corpus striatum</term><term>Dyskinesia</term><term>High uptake</term><term>Highest concentration</term><term>Involuntary movements</term><term>Malarial infection</term><term>Malarial patients</term><term>Medulla oblongata</term><term>Melanin</term><term>Melanin affinity</term><term>Nail beds</term><term>Osifo</term><term>Pituitary gland</term><term>Pyrogen</term><term>Pyrogen administration</term><term>Pyrogen pretreatment</term><term>Regional uptake</term><term>Respiratory distress</term><term>Reuptake mechanisms</term><term>Specific affinity</term><term>Striatum</term><term>Various regions</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The uptake of ip administered chloroquine diphosphate, 14 mg/ml/kg, into dissected regions of the rat brain with and without pyrogen pretreatment was investigated. A consistent pattern of uptake, not significantly altered by pyrogen pretreatment, was found. The highest concentration of chloroquine 1 hr after administration was found in the hypothalamus (1.278±0.114 μg/g; Mean ± SE), whereas the cortex (0.147±0.006 μg/g) had the lowest concentration. The corpus striatum (0.62±0.029 μg/g) had a smaller uptake than the hippocampus (0.693±0.011 μg/g), the cerebellum (0.676±0.055 μg/g), and the midbrain (0.644±0.053 μg/g). The difference of the uptake pattern from known catecholamine distribution in the rat brain leads to the conclusion that whereas no specific affinity of chloroquine for the catecholamine-rich regions have been proven, other unknown factors ensure a consistent pattern of chloroquine uptake. The implications of these findings in relation to the transient extrapyramidal disorders associated with the 4-aminoquinolines in some malarial patients, and the aberrant melanin pigmentation associated with the chronic use of chloroquine for some autoimmune diseases, are discussed.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Osifo, Nosakhare G" sort="Osifo, Nosakhare G" uniqKey="Osifo N" first="Nosakhare G." last="Osifo">Nosakhare G. Osifo</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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